Molecular Formula | C16H26O8 |
Molar Mass | 346.38 |
Density | 1.39±0.1 g/cm3(Predicted) |
Boling Point | 569.2±50.0 °C(Predicted) |
Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
Appearance | White crystalline powder |
pKa | 4.53±0.60(Predicted) |
Storage Condition | 2-8℃ |
MDL | MFCD31560801 |
Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Rehmannia glutinosa. |
Overview | rehmannioside is a terpenoid derived from rehmannia glutinosa, which is the fresh or dry root of the plant rehmannia glutinosa in the family scrofula. Rehmannia glutinosa is the root of the perennial herb rehmannia glutinosa, which is first recorded in the Shen Nong Herbal Classic and is listed as the top grade. It is one of the famous "four Huaiyao" in China. |
preparation | The dried R. The roots of glutinosa (20.0) were cut into small pieces and extracted twice with 95% EtOH for 2 hours under reflux conditions. The combined extracts were concentrated under reduced pressure, the concentrated solution (96.0 ml) was centrifuged and processed and then loaded onto Diaion HP-20 CC(12.5cm X) eluted sequentially with H2O and MeOH. An aqueous extract (1865.3g) and a methanol extract (101.6g) were sequentially obtained. Next, the methanol extract was dissolved in 10% ML (MeOH-H2O ml) and then placed on a Diaion HP-20(12.5cm × 96.0) column, again with 10%,30%,50%, 100%(v/v)MeOH-H2O(10 column volumes each) elution yields five fractions comprising Fr in succession. Fr.10% MeOH(65.0g),Fr.30% MeOH(16.6g),Fr.50% MeOH(11.5g),Fr.70% MeOH(4.2g) and Fr. 100% MeOH(2.0g). The 30% Me OH-H2O fraction was eluted with toopearl HW-40 CC and Fr. 1- 4 was obtained by eluting from 0% to 100% with MeOH-H2O. FR.1 (5.4g) was repeatedly chromatographed on silica to give 3(20.0mg) and 8(15.8mg). 3 is the rehmanniside. |
biological activity | Rehmapicroside is a kind of ionone glycoside isolated from the rhizome of rehmannia glutinosa. |